| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 2 | Second XI | 2021-11-20 | Murrumbeena | lost to | Mentone |
| 191 C Anstee 25 J Lockhart 42 | | 5/232 N Paranagama 2/24 |
| 1 | Twenty20 XI | 2021-11-23 | Murrumbeena | lost to | Parkdale |
| 9/177 B Kruger 76 | | 4/180 D Parkinson 2/23 |
| 3 | Second XI | 2021-11-27 | Heatherton | def | Murrumbeena |
| 181 Z Goold 2/33 J Anstee 3/13 T Fierenzi 2/26 | | 124 D Venturoni 25 |
| 4 | First XI | 2021-12-04 | Hampton |  | Murrumbeena |
| 158 D Parkinson 3/40 M Guruge 3/24 | | 7/187 A Hay 39 AR Ross 79 |
| 2 | Twenty20 XI | 2021-12-07 | St Brigids/St Louis | | Murrumbeena |
| 8/123 D Venturoni 2/18 N Paranagama 2/17 M Guruge 2/20 | | 5/125 B Kruger 27 |
| 5 | First XI | 2021-12-11 | Mordialloc | def | Murrumbeena |
| 9/141 N Karunarathne 2/19 M Guruge 2/12 N Paranagama 2/48 | | 139 |
| 3 | Twenty20 XI | 2021-12-14 | Middle Park | | Murrumbeena |
| 9/85 S Hillemacher 4/17 S Hawkins 2/16 | | 3/86 C Anstee 25 X Ross 26 |
| 6 | First XI | 2021-12-18 | Murrumbeena | | Bentleigh |
| 9/169 A Hay 29 B Kruger 32 | | 138 T Ryan 4/29 N Paranagama 3/35 |
| 8 | First XI | 2022-01-15 | Beaumaris | | Murrumbeena |
| 146 B Kruger 3/24 M Guruge 2/20 T Ryan 2/32 | | 7/147 B Kruger 80 |
| 9 | Second XI | 2022-01-22 | Mentone | def | Murrumbeena |
| 4/141 | | 137 J Bailey 34 J Martin 37 |
| 10 | Second XI | 2022-01-29 | Murrumbeena | lost to | Heatherton |
| 114 | | 9/276 S Hillemacher 4/49 P Chivers 2/61 N Paranagama 2/45 |
| 11 | Second XI | 2022-02-05 | Hampton | | Murrumbeena |
| 8/169 D Venturoni 2/18 S Hillemacher 2/36 | | 7/184 A Frangoulis 63 H Zandberg 38 |
| 12 | Second XI | 2022-02-12 | Mordialloc | def | Murrumbeena |
| 207 J Bailey 2/37 A Frangoulis 3/19 T Fierenzi 4/25 | | 193 J Flynn 71 H Zandberg 63 |
| 13 | Second XI | 2022-02-19 | Murrumbeena | lost to | McKinnon |
| 9/178 J Williams 26 A Frangoulis 52 | | 6/181 S Hillemacher 2/27 N Paranagama 2/38 |
